Transcriptome Patterns of BRCA1- and BRCA2- Mutated Breast and Ovarian Cancers

Mutations in the BRCA1 and BRCA2 genes are known risk factors drivers of breast ovarian cancers. So far, few studies have been focused on understanding differences transcriptome functional landscapes associated with disease (breast vs. cancers), gene (BRCA1 BRCA2), mutation type (germline somatic). In this study, we were aimed at systemic evaluation association germline somatic mutations expression, clinical features, outcome, treatment. We performed BRCA1/2 centered RNA-seq data analysis cancers from TCGA repository using phenotype “portrayal” multi-layer self-organizing maps annotation. The results revealed considerable BRCA1- BRCA2-dependent studied Furthermore, our indicated that for both characterized by deregulation different biological functions differential associations characteristics poly(ADP-ribose) polymerase (PARP)-inhibitor signatures. Overall, study demonstrates variation transcriptomic affected as well (somatic germline). These warrant further investigations larger groups carriers refining molecular mechanisms